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用冷冻断裂技术研究了月经周期不同阶段人子宫内膜腺上皮的紧密连接,发现在增生早期此连接的条纹数少,在质膜侧面的分布深度小。增生中期其条纹数比早期明显增加(P<0.05)。增生晚期及分泌早期,条纹数及分布深度比中期无明显增加(P>0.05)。与分泌早期相比,紧密连接在分泌中期的条纹数与分布深度都有显著增加(P<0.05)。分泌晚期,其条纹数及分布深度明显减少(P<0.01)。表明:人子宫内膜腺上皮紧密连接的结构随月经周期的过程变化,并提示紧密连接条纹数及其分布深度的增加(特别是分泌中期),可能与孕酮的作用有关。
Frozen fracture technique was used to study the tight junctions of human endometrial glandular epithelium at different stages of the menstrual cycle and found that the number of streaks in the early proliferative phase was small and the depth of distribution on the lateral side of the plasma membrane was small. The number of streaks in the metaphase was significantly higher than that in the early stage (P <0.05). In late stage of proliferation and early stage of secretion, the number of streaks and the distribution depth had no significant increase compared with the mid-stage (P> 0.05). Compared with the early stage of secretion, tight junction in the middle of the secretion of streak number and depth of distribution have increased significantly (P <0.05). Late secretion, the number of stripes and the depth of distribution was significantly reduced (P <0.01). The results showed that the structure of tight junctions of human endometrial glandular epithelium changed with the process of menstrual cycle and suggested that the number of tight junctions and the increase of their distribution depth (especially in the middle of secretion) may be related to the effect of progesterone.