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自80年代以来,难防难治的梭曼已成为世界防化研究的主攻目标。其主要原因是由于梭曼中毒酶老化快,梭曼结构中频哪基的空间位阻障碍着重活化剂的效能和梭曼的毒性强等。为此,对梭曼中毒酶重活化剂的研究是至关重要的。对神经性毒剂梭曼的防治水平可作为衡量一个国家防化医学研究水平的标志。 50年代推出的肟类重活化剂如2—PAM(含不同盐)和TMB—4等,抗梭曼无效,对梭曼中毒酶也无重活化作用。70年代出现一系列“H”肟类季铵盐化合物是文献报道的治疗梭曼中毒很有效的一类重活化剂,其中HI-6疗效最佳并对膈肌等梭曼中毒酶有确切的部分重活化作用。
Since the 80’s, the so-called “Soman” has become the main target of anti-chemical research in the world. The main reason is due to Soman toxin fast aging, soman structure intermediate-frequency steric hindrance barrier activator performance and Soman’s toxicity and so on. For this reason, the research on soman toxin reactivators is crucial. Soman’s control of neurotoxic agents can be used as a measure of the level of a national anti-chemical medicine. In the 1950s, oxime reactivators such as 2-PAM (including different salts) and TMB-4 were not effective against soman and no reactivation of soman toxin. In the 1970s, a series of “H” oxime quaternary ammonium compounds were reported in the literature as a very effective class of activators for the treatment of soman poisoning, of which HI-6 is the most effective and has an exact part of the somatotrophin enzyme such as diaphragm Activation of the role.