胃癌是临床上常见的消化道恶性肿瘤之一,由于多数患者首诊时已为中晚期,失去手术机会,故以化疗为主的综合治疗是其主要治疗手段,但因胃癌耐药,特别是MDR(multidrug resistance,MDR)是肿瘤化疗失败的关键因素。近年来,有关MDR形成机制研究已经成为国内外研究的热点之一,并有了较 Gastric cancer is one of the most common gastrointestinal malignancies in clinical practice. Since most of the patients have been diagnosed as having advanced stage and lost the chance of surgery, chemotherapy-based comprehensive treatment is the main treatment. However, gastric cancer is resistant, especially MDR (multidrug resistance, MDR) is the key factor of tumor chemotherapy failure. In recent years, the research on the formation mechanism of MDR has become one of the hot spots at home and abroad,