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目的:对盐酸氟西汀的有关物质进行检查。方法分别采用薄层色谱法和高效液相色谱法检查。结果薄层色谱法未能检出有关物质,而高效液相色谱法能够检出氟西汀的有关物质。结论采用高效液相色谱法可以检出盐酸氟西汀的有关物质,并确立了用高效液相色谱法的条件和控制有关物质的方法
Objective: To examine the related substances of fluoxetine hydrochloride. Methods TLC and HPLC were used respectively. Results Thin-layer chromatography failed to detect the relevant substances, and high-performance liquid chromatography to detect fluoxetine related substances. Conclusion High performance liquid chromatography can be used to detect the related substances of fluoxetine hydrochloride and establish the conditions of using high performance liquid chromatography and the methods of controlling related substances