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目的 :观察维生素D3 和葡萄糖酸钙对佝偻病的治疗作用。方法 :把佝偻病患儿分为非药物治疗对照组 (Ⅰ )、维生素D3治疗组 (Ⅱ )和维生素D3 加葡萄糖酸钙治疗组 (Ⅲ ) ,分别测定治疗前后血钙 (Ca)、磷 (P)、镁 (Mg)、碱性磷酸酶 (TALP)。结果 :佝偻病患儿Ⅱ、Ⅲ组治疗后 ,血Ca、P、Mg有所提高 ,TALP明显降低 ,并以Ⅲ组为明显 ,Ⅰ、Ⅱ、Ⅲ组治疗前后各指标经t检验差异有显著性(P<0 01)。结论 :维生素D3 葡萄糖酸钙对佝偻病都有较好治疗作用 ,两药联合使用 ,效果更好。维生素D3 和葡萄糖酸钙在防治佝偻病方面存在协同作用
Objective: To observe the therapeutic effect of vitamin D3 and calcium gluconate on rickets. Methods: The children with rickets were divided into non-drug treatment control group (Ⅰ), vitamin D3 treatment group (Ⅱ) and vitamin D3 plus calcium gluconate treatment group (Ⅲ). The levels of serum Ca, ), Magnesium (Mg), alkaline phosphatase (TALP). Results: The levels of Ca, P, Mg, TALP were significantly decreased in group Ⅱ and group Ⅲ after treatment. The level of TALP in group Ⅱ and Ⅲ was significantly lower than that in group Ⅲ, and there was significant difference between group Ⅰ, Ⅱ and Ⅲ before and after treatment (P <0.01). Conclusion: Vitamin D3 calcium gluconate have a good therapeutic effect on rickets, the two drugs combined effect is better. Vitamin D3 and calcium gluconate have synergistic effects in the prevention and treatment of rickets