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120例患中耳炎的小儿,分别用复方新诺明(组1),复方新诺明加叶酸(组2)和阿摩西林(组3)治疗,每组均为40例,按治疗量用10天。评审血液方面异常改变的发生率。观察到只有嗜酸细胞增多(绝对值≥0.5×10~9/L)(组1为10%,组2为5%,组3为7.5%)和中性白细胞减少(多形核中性白细胞≤1.5×10~9/L),(组1为35%,组2为17.5%,组3为13.3%)。早期中性白细胞减少(出现在治疗的第5天)3个组均出现,与复方新诺明应用无关。绝大部分病儿中性白细胞恢复正常而没有停药。后期
120 cases of children suffering from otitis media were treated with cotrimoxazole (group 1), cotrimoxazole (group 2) and amoxicillin (group 3), each group was 40 cases, the treatment of 10 day. Assess the incidence of abnormal changes in blood. Only eosinophilia (absolute value ≥ 0.5 × 10 ~ 9 / L) was observed (group 1 10%, group 2 5%, group 3 7.5%) and neutropenia (polymorphonuclear neutrophils ≤1.5 × 10 ~ 9 / L) (35% in group 1, 17.5% in group 2 and 13.3% in group 3). Early neutropenia (appearing on the 5th day of treatment) occurred in all 3 groups, not with cotrimoxazole. The vast majority of sick children neutrophils returned to normal without stopping. Late