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目的探讨肝炎肝硬化并发自发性细菌性腹膜炎(SBP)患者腹水中内毒素(LPS)、肿瘤坏死因子(TNFα)、降钙素原(PCT)水平的变化及其临床意义。方法所有肝炎肝硬化并发腹水患者作腹水LPS、TNFα和PCT水平检测,所有SBP患者腹水均作细菌培养。结果97例SBP患者腹水LPS、TNFα、PCT水平明显高于86例无SBP患者(P均<0.01),G-菌SBP腹水中的LPS、TNFα水平明显高于G+菌SBP腹水(P均<0.01)。结论腹水LPS、TNFα、PCT水平的检测有助于SBP的诊断,并且腹水LPS、TNFα水平的检测还有助于SBP病原菌的鉴别。
Objective To investigate the changes of the levels of endotoxin (LPS), tumor necrosis factor (TNFα) and procalcitonin (PCT) in ascites of patients with hepatic cirrhosis complicated with spontaneous bacterial peritonitis (SBP) and its clinical significance. Methods All patients with liver cirrhosis complicated with ascites were tested for ascites LPS, TNFα and PCT levels, and all ascites of SBP patients were used for bacterial culture. Results The ascites LPS, TNFα and PCT levels in 97 patients with SBP were significantly higher than those in 86 patients without SBP (all P <0.01). The levels of LPS and TNFα in ascites of G-bacteria SBP were significantly higher than those of G-bacteria SBP ascites ). Conclusion The detection of ascites LPS, TNFα, PCT levels is helpful for the diagnosis of SBP, and the detection of ascites LPS, TNFα levels also contribute to the identification of SBP pathogens.