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目的 :探讨癌基因c erbB 2在肝细胞癌癌变过程中的作用。方法 :用免疫组化检测 5例正常肝、 33例癌旁肝、 35例肝细胞癌组织中c erbB 2蛋白表达。结果 :① 6 8例癌旁肝和肝癌组织中部分病例检测到c erbB 2蛋白 ;②癌旁小细胞性肝细胞非典型增生 (SLCD) ,癌旁肝硬化 ,分化较好肝癌 ,分化较差肝癌c erbB 2蛋白阳性率分别为 10 0 % ,81 82 % ,45 45 % ,2 9 17% ,即癌旁组明显高于肝癌组 ;③c erbB 2蛋白阳性物以胞浆和胞膜两种形式存在 ,分布于癌旁SLCD、癌旁肝硬化肝细胞、肝硬化周围卵圆细胞、胆小管和肝癌细胞 ,以卵圆细胞染色最强。结论 :c erbB 2癌基因在肝细胞癌癌变过程中起一定作用 ,即癌变早期阶段。肝硬化周围胆小管细胞 ,卵圆细胞 ,SLCD细胞等发生转化 ,在癌变过程中扮演重要角色。
Objective: To investigate the role of oncogene c erbB 2 in carcinogenesis of hepatocellular carcinoma. Methods : The expression of c erbB 2 protein was detected by immunohistochemistry in 5 cases of normal liver, 33 cases of adjacent liver and 35 cases of hepatocellular carcinoma. Results: c erbB 2 protein was detected in 168 cases of paraneoplastic and hepatocellular carcinoma tissues; 2 paraneoplastic hepatocyte atypical hyperplasia (SLCD), paraneoplastic cirrhosis, well-differentiated liver cancer, poor differentiation The positive rate of hepatoma c erbB 2 protein was 100%, 81 82%, 45 45%, 199 17%, respectively, which was significantly higher in the paracancer group than in the hepatoma group; 3c erbB 2 protein positive was cytoplasm and membrane It exists in the form of paraneoplastic SLCD, paracancerous cirrhosis liver cells, perihepatic oval cells, bile canaliculi and hepatocarcinoma cells, and is most strongly stained with oval cells. Conclusion: The c erbB 2 oncogene plays a role in the carcinogenesis of hepatocellular carcinoma, which is the early stage of carcinogenesis. Cystic cells around the liver cirrhosis, oval cells, SLCD cells and other transformation, play an important role in the process of cancer.