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本文报导云南产蒙自藜芦的药理研究.给麻醉猫静脉注射0.1克/公斤后血压立即下降,最低降压率为52—72％.降压维持时间在1—2小时以上.反复给药无快速耐受现象.对心脏微增收缩振幅或无明显的作用.降压机制主要是作用于颈动脉竇及心肺感受区反射性地引起血压下降.该药对中枢有兴奋作用,对血管无直接作用,亦不具抗肾上腺素的作用.所含的主要降压成分可能为protoverine型结构的酯类生物碱, 小鼠口服LD-(50)为20±3克/公斤.
In this paper, pharmacological studies on Yunnan-made veratridine were reported.The blood pressure dropped immediately after intravenous injection of 0.1 g / kg anesthesia cats and the minimum pressure-lowering rate was 52-72% .The antihypertensive maintenance time was over 1-2 hours. No rapid tolerance of the heart micro-increase or contraction amplitude or no significant role in the mechanism of antihypertensive effect is mainly on the carotid sinus and cardiorespiratory reflex caused by the decline in blood pressure.This drug has an excitement on the central, no vascular Direct action, nor anti-adrenergic effect. The main antihypertensive component may be protofrussine ester alkaloid structure, the mouse oral LD- (50) of 20 ± 3 g / kg.