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目的:探讨癌胚抗原黏附分子1(CEACAM1)在甲状腺癌患者外周血中水平及其对甲状腺癌的诊断价值。方法:用ELISA法检测76例甲状腺癌患者、48例甲状腺良性肿瘤患者和38例健康体检者外周血中CEACAM1水平,同时检测所有入组样本的癌胚抗原(CEA)及甲状腺球蛋白(TG)水平,分析外周血CEACAM1水平与甲状腺癌临床病理特征的关系,制作ROC曲线,比较CEACAM1、CEA、TG对甲状腺癌的诊断价值。结果:甲状腺癌患者血清CEACAM1水平明显高于甲状腺良性肿瘤患者及健康对照者(547.11 ng/mL vs.469.77 ng/mL、369.04 ng/mL,均P<0.05)。血清CEACAM1水平与甲状腺癌的TNM分期和淋巴结转移有关(均P<0.05)。血清CEACAM1水平诊断甲状腺癌的ROC曲线下面积为0.94,敏感性97.4%,特异性80.3%,CEACAM1对甲状腺癌的诊断价值优于CEA和TG。结论:血清CEACAM1检测对甲状腺癌的诊断及其病情评估有一定意义。
Objective: To investigate the level of carcinoembryonic antigen-1 (CEACAM1) in peripheral blood of patients with thyroid cancer and its diagnostic value for thyroid cancer. Methods: The CEACAM1 levels in peripheral blood of 76 patients with thyroid cancer, 48 patients with thyroid benign tumor and 38 healthy controls were detected by ELISA. The CEA and TG of all the samples were detected simultaneously. Level, analyze the relationship between CEACAM1 levels in peripheral blood and clinicopathological features of thyroid carcinoma, and make ROC curves to compare the diagnostic value of CEACAM1, CEA and TG in the diagnosis of thyroid carcinoma. Results: Serum CEACAM1 levels in patients with thyroid cancer were significantly higher than those in benign thyroid tumors and healthy controls (547.11 ng / mL vs. 469.77 ng / mL, 369.04 ng / mL, all P <0.05). The level of serum CEACAM1 was correlated with TNM stage and lymph node metastasis of thyroid cancer (all P <0.05). The area under the ROC curve of serum CEACAM1 in the diagnosis of thyroid cancer was 0.94, the sensitivity was 97.4% and the specificity was 80.3%. The diagnostic value of CEACAM1 in thyroid cancer was better than that in CEA and TG. Conclusion: Serum CEACAM1 detection of thyroid cancer diagnosis and evaluation of the disease have some significance.