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目的:观察吉祥戒毒液对小鼠的镇痛作用及急性毒性反应。方法:镇痛作用采用小鼠冰乙酸扭体法。急性毒性反应采用一次给药观察7d的实验方法,按Bliss法计算吉祥戒毒液LD50。结果:(1)镇痛实验中,与对照组比较,吉祥戒毒液组小鼠平均扭体次数减少,差异均有显著性意义(P<0.05)。(2)小鼠口服给药的LD50为110.2g/kg。结论:(1)吉祥戒毒液20-40g/kg具有较好的镇痛作用,并可能对缓解海洛因依赖戒断综合征中的疼痛有一定帮助,是治疗阿片类药物依赖的有效药物。(2)吉祥戒毒液小鼠LD50相当于临床用药量的11倍以上,几乎没有毒性,临床口服用药量是安全的。
Objective: To observe the analgesic effect and acute toxicity of Jixiang Reagent on mice. Methods: analgesic effect using mouse acetic acid writhing method. Acute toxicity was observed using a single administration of experimental methods 7d, according to Bliss method to calculate auspicious detoxification LD50. Results: (1) Compared with the control group, the mean number of writhing in the Jixiang Rehmanniae Decoction group was significantly decreased (P <0.05). (2) The LD50 of mice administered orally was 110.2 g / kg. Conclusion: (1) 20-40g / kg of auspicious detoxification liquid has good analgesic effect and may be helpful to relieve the pain in heroin addicted withdrawal syndrome and is an effective drug for the treatment of opioid dependence. (2) Jixiang detoxification mouse LD50 is equivalent to more than 11 times the clinical dose, almost no toxicity, clinical oral dose is safe.