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目的探讨我县应用乙肝免疫球蛋白和乙肝疫苗联合免疫阻断乙肝母婴传播的效果。方法随机抽取223例HBsAg阳性孕妇,选取其中113例设定为观察组,此组分别于孕28、32、36周时肌肉注射乙肝免疫球蛋白(HBIG200IU),110例未注射乙肝免疫球蛋白(HBIG200IU)的设定为对照组。所有新生儿出生后24h内注射HBIG200IU,并按0、1、6月龄接种国产酵母乙肝疫苗10μg/次,随访至12月龄,采用酶联免疫法检测新生儿出生时和12月龄时的血清乙肝“两对半”指标。结果观察组新生儿宫内感染率为1.77%,12月龄时具有保护性抗体的有效保护率为94.69%;对照组新生儿宫内感染率为8.18%,12月龄时具有保护性抗体的有效保护率为75.45%,两组相比具有统计学意义。结论乙肝免疫球蛋白(HBIG)与乙肝疫苗联合免疫可明显减少宫内感染的发生和有效阻断HBV的母婴垂直传播。
Objective To investigate the effect of combined immunization of hepatitis B immunoglobulin and hepatitis B vaccine on mother-to-child transmission of hepatitis B in our county. Methods A total of 223 HBsAg positive pregnant women were randomly selected and 113 of them were selected as the observation group. The rats were intramuscularly injected with HBIG200IU at 28,32 and 36 weeks of pregnancy, and 110 cases without hepatitis B immunoglobulin HBIG200IU) is set as the control group. All neonates were injected intraperitoneally with HBIG200IU within 24 hours after birth, and domestic yeast hepatitis B vaccine (10μg / dose) was inoculated at 0, 1 and 6 months of age, followed up to 12 months of age. Enzyme linked immunosorbent assay Serum hepatitis B “two and a half ” indicator. Results The intrauterine infection rate in the observation group was 1.77%. The effective protection rate of protective antibodies at 12 months of age was 94.69%. The neonatal intrauterine infection rate in the control group was 8.18%, and the protective antibody at 12 months of age Effective protection rate was 75.45%, compared with the two groups was statistically significant. Conclusion Combined immunization with hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine can significantly reduce the incidence of intrauterine infection and effectively block the vertical transmission of HBV from mother to infant.