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浆细胞样树突状细胞(plasmacytoid dendritic cell,pDC)从1958年被发现,其定位于活动性淋巴结周围,呈浆细胞形态,后续的研究发现这些细胞表达T细胞和单核细胞的表面标记,并且在病毒刺激后迅速产生大量的Ⅰ型干扰素,结合其生物学形态特征、定位、表型及功能,这群细胞曾被称为T细胞样浆细胞、单核细胞样浆细胞、Ⅰ型干扰素生成细胞。根据近年的研究明确这群细胞具有抗原提呈功能,现公认使用浆细胞样树突[1]
Plasmacytoid dendritic cells (pDC) were discovered in 1958 and located around the active lymph nodes in a plasma cell morphology. Subsequent studies found that these cells expressed T-cell and monocyte surface markers, In addition, a large number of type I interferons are produced rapidly after virus stimulation. Combined with their biological morphological characteristics, localization, phenotype and function, these cells have been called as T-cell-like plasma cells, monocyte-like plasmacytoid cells, Interferon-producing cells. According to recent studies clear that these cells have antigen presenting function, it is recognized that the use of plasmacytoid dendrites [1]