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目的:探讨子宫内膜异位症(EM)患者细胞因子和子宫内膜抗体(EM Ab)的变化及与临床的关系。方法:应用酶联免疫(ELISA)和放射免疫(RIA)技术对EM患者(75例)和正常对照组(30例)进行细胞因子(IL-6、TNF-α和sIL-2R)、EM Ab和CA 125含量的测定;并动态观察经手术和内美通(Nemestran)治疗3个月后的EM患者(25例)的细胞因子和EM Ab的变化。结果:与对照组比较EM患者的这些细胞因子和EM Ab水平均升高(均P<0.01),EMAb含量与IL-6水平之间呈正相关(r=0.674,P<0.01)。患者于治疗前后的细胞因子和EM Ab水平也有显著性差异(均P<0.01)。结论:细胞因子和自身抗体EMAb的变化对于EM发病机理的探讨和疾病的诊断及疗效观察可提供重要的实验依据。
Objective: To investigate the changes of cytokines and endometrial antibodies (EM Ab) in patients with endometriosis (EM) and its clinical significance. Methods: The levels of IL-6, TNF-α and sIL-2R, EM Ab in EM patients (75 cases) and normal control group (30 cases) were detected by enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay (RIA) And CA125 levels were determined. The changes of cytokines and EM Ab in EM patients (25 cases) after 3 months of operation and Nemestran treatment were dynamically observed. Results: Compared with the control group, the levels of these cytokines and EM Ab in patients with EM were significantly increased (all P <0.01). There was a positive correlation between the levels of EMAb and IL-6 (r = 0.674, P <0.01). The levels of cytokines and EM Ab in patients before and after treatment were also significantly different (all P <0.01). Conclusion: The changes of cytokine and autoantibody EMAb may provide important experimental evidence for the pathogenesis of EM and the diagnosis and curative effect of the disease.