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目的分析妊娠对卵巢过度刺激综合征(OHSS)的病程的影响及临床特征。方法回顾性分析广州医科大学附属第三医院2008年1月至2013年12月行超促排卵中发生中、重度OHSS共97例,按是否妊娠,分为未妊娠组(n=40)和妊娠组(n=57),分析两组的平均取卵个数、平均卵巢直径、发病时间、住院时间、各种并发症的发生率等。结果妊娠组的取卵数及平均卵巢直径均较未妊娠组低,差异有统计学意义(P<0.05);妊娠组的发病时间较未妊娠组短、住院时间较未妊娠组长,差异均有统计学意义(P<0.001)。妊娠组重度OHSS发生率较未妊娠组高,两者比较差异有统计学意义(P<0.001)。妊娠组并发胸腹水、血液浓缩、少尿、低蛋白血症、行腹水穿刺的次数显著高于未妊娠组,差异有统计学意义(P<0.05)。结论妊娠可以导致OHSS病程迁延,加重病情。
Objective To analyze the influence and clinical characteristics of pregnancy on the course of ovarian hyperstimulation syndrome (OHSS). Methods A total of 97 moderate and severe OHSS cases were performed in the third affiliated hospital of Guangzhou Medical University from January 2008 to December 2013. The patients were divided into two groups according to whether they were pregnant or not, including non-pregnant group (n = 40) and pregnancy (N = 57). The average number of ovulation, average ovarian diameter, time of onset, length of hospital stay, and the incidence of various complications in both groups were analyzed. Results The number of ovulation and average ovarian diameter in pregnancy group were significantly lower than those in non-pregnancy group (P <0.05). The incidence of pregnancy in pregnancy group was shorter than that in non-pregnancy group, and the length of hospital stay was longer than that of non-pregnancy group There was statistical significance (P <0.001). The incidence of severe OHSS in pregnancy group was higher than that in non-pregnancy group, the difference was statistically significant (P <0.001). Pregnancy group had pleural effusion and ascites, blood concentration, oliguria, hypoproteinemia, the number of ascites puncture was significantly higher than that of non-pregnant group, the difference was statistically significant (P <0.05). Conclusion Pregnancy can lead to prolonged OHSS course and aggravate the disease.