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目的检测慢性硬膜下血肿(CSDH)外膜中转化生长因子-β1(TGF-β1)的表达情况。方法应用免疫组化检测32名慢性硬膜下血肿患者血肿外膜中TGF-β1的表达情况。在5个高倍视野下每张切片中的成纤维细胞、血管内皮细胞、炎细胞数大于500个为富于细胞组,共16例,在100~500之间为较丰富细胞组,共12例,小于100个为缺乏细胞组,共4例。结果 TGF-β1在富于细胞组表达呈强阳性,在较丰富细胞组表达呈阳性。结论 TGF-β1促进血肿外膜新生血管生成,促进血肿外膜纤维化。
Objective To detect the expression of transforming growth factor-β1 (TGF-β1) in the epidural membrane of chronic subdural hematoma (CSDH). Methods Immunohistochemistry was used to detect the expression of TGF-β1 in the hematoma outer membrane of 32 patients with chronic subdural hematoma. At 5 high power fields, the number of fibroblasts, vascular endothelial cells and inflammatory cells in each section was more than 500 in the rich cell group, a total of 16 cases, between 100 and 500 for the more abundant cell group, a total of 12 cases , Less than 100 for the lack of cell group, a total of 4 cases. Results TGF-β1 was strongly positive in the rich cell group and positive in the more abundant cell group. Conclusion TGF-β1 can promote hemangioma adventitial angiogenesis and promote hematoma adventitial fibrosis.