皮肤真菌病是一种分布广、患病率高、慢性传染性疾病。灰黄霉素对其有比较满意的疗效,且副作用少,偶有副作用一般亦不影响治疗。但由于其应用范围广,服用时间长,则对它的安全要求亦愈高。近年来,通过做了大量的小白鼠口服大剂量微粒灰黄霉素的研究,它的毒性反应主要表现在卟啉代谢障碍及致癌作用两方面。1.卟啉代谢障碍。在小鼠饲料中加入1～2.5%灰黄霉素(约为人剂量的50～150倍), Skin fungal disease is a widely distributed, high prevalence of chronic infectious diseases. Griseofulvin has a more satisfactory curative effect, and less side effects, occasional side effects generally do not affect the treatment. However, due to its wide range of applications, taking a long time, the higher its safety requirements. In recent years, by doing a large number of oral administration of large doses of griseofulvin in mice, its toxicity mainly in the metabolism of porphyrin and carcinogenic effects in two aspects. 1. Porphyrin metabolism disorders. In the mouse feed 1 to 2.5% griseofulvin (about 50 to 150 times the human dose),