美尼尔氏病的发病与变态反应有关早在1892年即被认识;以后Hozawa(1980)否定了眩晕由Ⅰ型变态反应引起的可能性,提出与Ⅲ型变态反应有关。本文研究内淋巴、血管纹及其周围组织中是否存在IgG抗体和补体,以及内淋巴积水与Ⅲ型变态反应的关系。方法:(1)内淋巴I gG、补体的检测:实验动物为350～500g Hartley种健康豚鼠,Preyer氏反射阳性。采用常规方法以微量吸管收集内淋巴液,应用改良Mayer氏试验(1961)、I nai氏(1968,1977)和Levine氏(1961)法检测补体;应用免疫电泳和免疫扩散法检测IgG;内耳血管纹组织经处理后用萤光抗体法证实IgG Fc受体的存在;(2)内淋巴积水 The onset of Meniere’s disease was related to the allergic reaction as early as 1892; later Hozawa (1980) rejected the possibility of vertigo caused by type I allergy and was associated with type III allergy. This article studies whether there are IgG antibodies and complement in the endolymph, vascular pattern and surrounding tissues, and the relationship between endolymphatic hydrops and type III allergy. Methods: (1) Endolymph I gG, detection of complement: experimental animals were 350 ~ 500g Hartley healthy guinea pigs, Preyer’s reflex positive. Endolymph was collected using a micropipette using conventional methods. Complement was detected using the modified Mayer’s test (1961), I nai’s (1968, 1977), and Levine’s (1961) assays; IgG was detected by immunoelectrophoresis and immunodiffusion; Fluorescent antibody was used to confirm the presence of IgG Fc receptor after treated with tissue; (2) Endolymphatic hydrops