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目的:研究模拟宫腔液成分对铜/低密度聚乙烯(Cu/LDPE)纳米复合材料宫内节育器(IUD)中Cu2+释放的影响。方法:根据模拟宫腔液的成分和浓度配制了6种浸泡溶液,用紫外分光光度计测试复合材料IUD在浸泡溶液中Cu2+的释放速率,用标准接触角仪测试复合材料与浸泡溶液的接触角,用pH计测试浸泡溶液的pH值。结果:模拟宫腔液成分可改变溶液与复合材料的接触角,以及浸泡溶液的pH值,进而对复合材料IUD的Cu2+释放速率产生较大影响。含Cl-无机正盐、葡萄糖、人血白蛋白能加速Cu2+的释放,但酸式盐的加入使Cu2+释放速率降低。结论:模拟宫腔液成分对复合材料IUD的Cu2+释放速率产生较大影响。
Objective: To study the effects of uterine fluid composition on Cu2 + release in copper / low density polyethylene (Cu / LDPE) nanocomposite IUDs. Methods: According to the composition and concentration of uterine fluid, six kinds of soaking solution were prepared. The release rate of Cu2 + in IUD solution was measured by UV spectrophotometer. The contact angle between composite and soaking solution was measured by standard contact angle meter The pH value of the soaking solution was measured with a pH meter. Results: The simulated uterine fluid composition can change the contact angle between the solution and the composite and the pH of the soaking solution, which in turn has a great effect on the Cu2 + release rate of the composite IUD. Cl-containing inorganic salts, glucose and human serum albumin can accelerate the release of Cu2 +, but the addition of acid salt reduced the release rate of Cu2 +. Conclusion: The simulated uterine fluid composition has a great effect on Cu2 + release rate of IUD.