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[目的]观察中药联合免疫治疗肿瘤化疗后骨髓抑制(气血亏虚)的临床疗效。[方法]选择符合条件的60例病人按1∶1的比例随机分为治疗组与对照组,两组生物学和临床一般资料分布均衡,均无显著性差异。治疗组采用中药汤剂自拟二黄汤,药用黄芪、黄精各30g,当归、仙鹤草、鸡血藤各15g,川芎、枸杞子、菟丝子、木香各9g,颗粒阿胶、紫河车、大枣各2包冲服,水煎,取汁300mL,日1剂,1日2次,并配合免疫治疗,每日2次,每次30min,14d为1疗程。对照组给予重组人粒细胞集落刺激因子(瑞白)(齐鲁制药有限公司)1支(100μg),皮下注射,1日1次,连续治疗10d。[结果]治疗组治疗14d的总有效率为82.5%,治疗组与对照组的总有效率比较,有显著性差异。[结论]中药结合免疫治疗肿瘤化疗后骨髓抑制(气血亏虚)疗效显著,与西医对照组比较患者症状改善明显,疗效显著。
[Objective] To observe the clinical efficacy of combined immunotherapy of traditional Chinese medicine on bone marrow suppression (Qi and blood deficiency) after chemotherapy. [Methods] Sixty eligible patients were randomly divided into treatment group and control group according to the ratio of 1: 1. There was no significant difference in the distribution of general biological and clinical data between the two groups. The treatment group used traditional Chinese medicine decoction self-made two yellow soup, medicinal Astragalus, Polygonatum each 30g, Angelica, Agrimony, Millettia each 15g, Chuanxiong, medlar, dodder, woody each 9g, granulated donkey-hide gelatin, Jujube 2 packets of Chongfu, decoction, juice 300mL, day 1, 2 times on the 1st, and with immunotherapy, 2 times a day, each 30min, 14d for a course of treatment. Control group was given recombinant human granulocyte colony-stimulating factor (Swiss white) (Qilu Pharmaceutical Co., Ltd.) 1 (100μg), subcutaneous injection, 1 on the 1st, continuous treatment of 10d. [Results] The total effective rate of the treatment group was 82.5% after 14 days of treatment. The total effective rate of the treatment group and the control group was significantly different. [Conclusion] The myelosuppression (Qi and blood deficiency) after chemotherapy combined with traditional Chinese medicine combined with immunotherapy has significant curative effect. Compared with the western medicine control group, the symptoms of the patients are improved obviously and the curative effect is remarkable.