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应用本室先后建立的酶联免疫吸附法和核酸打点杂交法,检测我国25省布自治区、16个不同民族共9 758例乙型肝炎病毒感染者中的丁型肝炎病毒抗原、抗体和核酸。其中乙型肝炎病人4 714例,HBsAg慢性携带者5 044例。病人和携带者中丁型肝炎抗原阳性率分别为4.25％和3.0％,丁型肝炎抗体阳性率分别为1.46％和1.18％,丁型肝炎病毒核酸阳住率分别为3.70％和2.2％。在不同地区不同民族丁型肝炎的这些指标有一定差异。在16个民族中,维吾尔族、蒙族和藏族丁型肝炎抗体阳性率明显高于其他民族,黎族丁型肝炎核酸阳性率高于其他民族。但在1136例不同临床型乙型肝炎病人中,丁型肝炎感染率无明显区别。丁型肝炎感染与暴发性肝炎的关系有待进一步研究。
The hepatitis C virus antigens, antibodies and nucleic acids among 9 758 hepatitis B virus-infected persons in 25 ethnic autonomous regions and 16 ethnic groups in 25 provinces of China were detected by enzyme-linked immunosorbent assay and nucleic acid dot blot hybridization assay. Among them, 4 714 cases were hepatitis B patients and 5 044 cases were chronic carriers of HBsAg. The positive rates of hepatitis D antigen in patients and carriers were 4.25% and 3.0% respectively, the positive rates of hepatitis B and hepatitis B were 1.46% and 1.18% and 3.70% and 2.2% respectively. There are some differences in these indicators of hepatitis D in different ethnic groups in different regions. Among the 16 ethnic groups, the positive rate of hepatitis B antibodies among Uygur, Mongolian and Tibetan peoples is significantly higher than that of other ethnic groups. The positive rate of nucleic acid of Lebanon hepatitis D is higher than that of other ethnic groups. However, in 1136 cases of different clinical type of hepatitis B patients, hepatitis D infection rate no significant difference. The relationship between hepatitis B infection and fulminant hepatitis needs further study.