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目的:正交试验法优选解毒通络颗粒处方药材的提取工艺。方法:以出膏率、丹酚酸B及天麻素为考核指标,采用L9(34)正交试验考察解毒通络颗粒处方药材提取工艺条件。结果:解毒通络颗粒处方药材的最佳提取工艺为10倍量70%乙醇提取3次,每次提取1.5 h。结论:该提取工艺稳定可行,省时、省工、节能,适合于工业化大生产,为解毒通络颗粒的制剂研究奠定基础。
Objective: To optimize the extraction process of Jiedu Tongluo Granules prescription by orthogonal test. Methods: With the rate of ointment, salvianolic acid B and gastrodin as test indicators, the extraction conditions of Jiedu Tongluo Granules were studied by L9 (34) orthogonal test. Results: The optimum extraction process of Jiedu Tongluo Granules prescription was 10 times the amount of 70% ethanol extraction three times, each extraction 1.5 h. Conclusion: The extraction process is stable and feasible, saving time, saving labor, saving energy and being suitable for industrialized large-scale production, which lays the foundation for the formulation research of Jiedu Tongluo granules.