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阻塞性黄疸常继发于胆道内结石、胆道肿瘤或疤痕良性狭窄等疾病.已知胆管阻塞后胆管内压力升高,胆红素、胆盐逆流入血,从而对肝肾等器官造成各种损害.但对阻塞性黄疸病人免疫功能的改变情况则了解较少.本文就阻塞性黄疸病人机体免疫功能受影响的有关文献作一综述.一、阻塞性黄疸对胸腺和淋巴组织的抑制作用Pinto和Kaplun在结扎大白鼠胆总管(CBDL)后发现脾脏指数(脾脏重量/鼠体重×100%)明显增加,胸腺重量显著减少.与正常胸腺相比阻塞性黄疸鼠每克胸腺组织内总淋巴细胞数仅为正常胸腺淋巴细胞之1/3.光镜下见胸腺皮质和髓质区缩小,大部分胸腺实质被结缔组织代替;脾脏肿大,但镜下无异常改变.
Obstructive jaundice often secondary to biliary stones, biliary tumors or benign scar stenosis and other diseases known bile duct obstruction after bile duct pressure increases, bilirubin, bile salts into the bloodstream, resulting in various organs such as liver and kidney Damage.But for patients with obstructive jaundice changes in immune function is less understood.This article reviews the literature on the impact of immune function in patients with obstructive jaundice.One, the inhibitory effect of obstructive jaundice on thymus and lymphoid tissue Pinto And Kaplun showed a significant increase in spleen index (spleen weight / body weight × 100%) and a significant reduction in thymus weight after ligation of rat common bile duct (CBDL). Compared with normal thymus, the total lymphocytes per gram of thymus The number of normal thymic lymphocytes is only 1 / 3. Under the light microscope, see the thymus cortex and medulla area shrink most of the thymus is replaced by connective tissue; splenomegaly, but no abnormal changes in the microscope.