论文部分内容阅读
Dear Editor,A few studies have focused on exploring APOE generelated effects on cognitive functions and brain activities in healthy populations.Bondi et al.found thatε4 carriers perform significantly worse on the California Verbal Learning Test than non-carriers in non-demented old subjects(mean age,72 years)[1].B ut the results are not entirely consistent.For example,Scarmeas et al.found no effect of theε4 allele on neuropsychological performance[2]in young adults,and Jochemsen et al.found that theε4allele is associated with age-related cognitive decline[3].Furthermore,protective and negative effects of theε2allele on cognition are inconsistent[4,5].APOEε2 is thought
Dear Editor, A few studies have focused on exploring APOE generelated effects on cognitive functions and brain activities in healthy populations. Bondi et al. Found that ε4 carriers perform dramatically worse on the California Verbal Learning Test than non-carriers in non-demented old subjects ( For example, Scarmeas et al. found no effect of the ε4 allele on neuropsychological performance [2] in young adults, and Jochemsen et al. found that the ε4allele is associated with age-related cognitive decline [3] .Furthermore, protective and negative effects of theε2allele on cognition are inconsistent [4,5] .APOEε2 is thought