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BACKGROUND:?Ischemic?preconditioning?(IPC)?has?been?shown?to?decrease?liver?injury?and?to?increase?hepatic?microvascular?perfusion?after?liver?ischemia?reperfusion.?This?study?aimed?to?evaluate?the?effects?of?IPC?on?hemodynamics?of?the?portal?venous?system. METHODS:?Thirty-two? rats? were? randomized? into? two?groups:?IPC?group?and?control?group.?The?rats?of?the?IPC?group?underwent?IPC?by?10?minutes?of?liver?ischemia?followed?by?10?minutes?of?reperfusion?before?liver?ischemia,?and?the?rats?of?the?control?group?were?subjected?to?60?minutes?of?partial?liver?ischemia.?Non-ischemic?lobes?were?resected?immediately?after?reperfusion.?The?animals?were?studied?at?4?hours?and?12?hours?after?reperfusion.?Mean?arterial?pressure,?heart?rate,?portal?vein?lfow?and?pressure?were?analyzed.?Blood?was?collected?for?the?determination?of?the?levels?of?aspartate?aminotransferase,?alanine?aminotransferase,?calcium,?lactate,?pH,?bicarbonate,?and?base?excess. RESULTS:?IPC?increased?the?mean?portal?vein?lfow?at?4?hours?and?12?hours?after?reperfusion.?IPC?recovered?78%?of?the?mean?portal?vein?lfow?at?12?hours?after?reperfusion.?IPC?decreased?the?levels?of?aspartate?aminotransferase,?alanine?aminotransferase?and? lactate,? and? increased? the? levels? of? ionized? calcium,?bicarbonate?and?base?excess?at?12?hours?after?reperfusion. CONCLUSIONS:?This?study?demonstrated?that?IPC?increases?portal? vein? lfow? and? enhances? hepatoprotective? effects? in?liver? ischemia? reperfusion.? The? better? recovery? of? portal?vein?lfow?after?IPC?may?be?correlated?with?the?lower?levels?of?transaminases?and?with?the?better?metabolic?proifle.