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目的 :探讨居住海拔 50 0 0m以上地区人群睡眠血氧饱和度 (SaO2 )的变化以及复方红景天和乙酰唑胺的调节作用 ;方法 :对居住海拔 53 80m一年的 2 4名青年随机分为A组 (红景天组 )、B组 (乙酰唑胺组 )和C组 (红景天 +乙酰唑胺组 ) ,每组 8人 ,在服药前和服药 2 4天后分别进行睡眠SaO2 监测 ;结果 :服药后较服药前清醒时SaO2 (WSaO2 )、睡眠监测过程中最低SaO2 (LSaO2 )和平均SaO2 (MSaO2 )均增高 ,氧减饱和度指数 (DI4 )及SaO2 ≤ 80 %的时间占总监测时间的百分比 (SIT80 )均降低 ,差别有非常显著性 (P <0 .0 1 ) ;服药后B组和C组与A组比较 ,SIT80 升高 ,差别有显著性 (P <0 .0 5) ;WSaO2 、LSaO2 、MSaO2 及DI4 各组间比较均无统计学意义 (P >0 .0 5) ;结论 :复方红景天和乙酰唑胺均能明显提高睡眠SaO2 ,在减小SIT80 方面复方红景天有优于乙酰唑胺的趋势 ,但两种药物合用并无明确的协同作用
Objective: To investigate the change of sleep oxygen saturation (SaO2) and the regulation effect of compound Rhodiola and acetazolamide in residential areas above 50 000 m above sea level.Methods: 24 youth aged 53 80m A group (Rhodiola group), B group (acetazolamide group) and C group (Rhodiola + acetazolamide group), 8 in each group, before taking the medication and 24 days after taking sleep SaO2 monitoring Results: SaO2 (WSaO2), SaO2 (LSaO2) and mean SaO2 (MSaO2) during sleep monitoring were significantly higher than those before treatment, and oxygen desaturation index (DI4) and SaO2 ≤ 80% The percentage of monitoring time (SIT80) decreased, the difference was significant (P <0.01); after treatment, the levels of SIT80 in group B and C were significantly higher than those in group A (P <0. 0 5). There was no significant difference between WSaO2, LSaO2, MSaO2 and DI4 groups (P> 0.05) .Conclusion: Both Rhodiola and Acetazolamide can significantly improve sleep SaO2, reduce SIT80 Compound Rhodiola has better than acetazolamide trend, but there is no clear synergy between the two drugs combined