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目的:探讨中西医结合治疗中晚期非小细胞性肺癌的临床疗效。方法:将59例中晚期非小细胞性肺癌患者分为实验组35例和对照组24例。对照组采用单纯化疗进行治疗,实验组患者采用以益气养阴解毒化痰为主的中药结合常规化疗进行治疗。治疗2个疗程后比较两组患者临床疗效以及sIL-2R、TNF-α结果。结果:实验组和对照组患者经2个疗程治疗后,近期治疗有效率分别为28.6%、20.8%,两组差异无统计学意义(P>0.05);两组患者的瘤体稳定率分别为82.9%、66.7%,两组比较差异有统计学意义(P<0.05);两组患者sIL-2R均显著下降,同时TNF-α显著升高,但实验组患者变化较对照组更为显著(P<0.05)。结论:以益气养阴解毒化痰为主的中药结合常规化疗治疗方法能够显著抑制肿瘤的发展,稳定瘤体,提高患者的免疫功能,临床疗效显著,值得临床推广应用。
Objective: To explore the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of advanced non-small cell lung cancer. Methods: Fifty-nine patients with advanced non-small cell lung cancer were divided into experimental group (35 cases) and control group (24 cases). The control group was treated with chemotherapy alone. The patients in the experimental group were treated with traditional Chinese medicine combined with conventional chemotherapy, mainly on the basis of Yiqi Yangyin, detoxification and phlegm. After two courses of treatment, the clinical efficacy and the results of sIL-2R and TNF-α were compared between the two groups. Results: After two courses of treatment, the effective rates of treatment in the experimental group and control group were 28.6% and 20.8% respectively, there was no significant difference between the two groups (P> 0.05). The stability rates of the two groups were 82.9% and 66.7%, respectively. There was significant difference between the two groups (P <0.05). The sIL-2R in both groups decreased significantly and TNF-α significantly increased at the same time P <0.05). CONCLUSION: Traditional Chinese medicine combined with conventional chemotherapy with Yiqi Yangyin, Detoxifying and Phlegm-based Therapy can significantly inhibit tumor development, stabilize the tumor and improve patients’ immune function. The clinical effect is significant and worthy of clinical application.