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用活化的抗癌药物氨甲喋呤（ＭＴＸ）和羊抗鼠ＩｇＧ（ＳＡＭＩｇＧ）共价结合，制备ＳＡＭＩｇＧ－ＭＴＸ结合物，通过ＣＥＡ单抗（ＭｃＡｂ）的介导，ＳＡＭＩｇＧ－ＭＴＸ能选择性地杀伤ＣＥＡ＋细胞，其选择细胞毒作用是ＣＥＡＭｃＡｂ－ＭＴＸ结合物的２倍，提示间接导向治疗具有简便、经济、高效的特点。
SAMIgG-MTX conjugates were prepared by covalent attachment of activated anti-cancer drug methotrexate (MTX) and goat anti-mouse IgG (SAMIgG). SAMIgG-MTX could selectively kill CEA + cells mediated by CEA McAb , Its choice of cytotoxicity is 2 times that of CEAMcAb-MTX conjugate, suggesting that Indirect Guidance is simple, economical and efficient.