论文部分内容阅读
用活化的抗癌药物氨甲喋呤(MTX)和羊抗鼠IgG(SAMIgG)共价结合,制备SAMIgG-MTX结合物,通过CEA单抗(McAb)的介导,SAMIgG-MTX能选择性地杀伤CEA+细胞,其选择细胞毒作用是CEAMcAb-MTX结合物的2倍,提示间接导向治疗具有简便、经济、高效的特点。
SAMIgG-MTX conjugates were prepared by covalent attachment of activated anti-cancer drug methotrexate (MTX) and goat anti-mouse IgG (SAMIgG). SAMIgG-MTX could selectively kill CEA + cells mediated by CEA McAb , Its choice of cytotoxicity is 2 times that of CEAMcAb-MTX conjugate, suggesting that Indirect Guidance is simple, economical and efficient.