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研究了人类和大鼠的心脏α和 β 肌球蛋白重链基因中的嘧啶基比例。编码MyHC尾的外显子均是缺少嘧啶基的。这一特殊发现 ,即某些内含子是富嘧啶基的 ,而此种富嘧啶基状态在人类和大鼠均有保留 ,使所有四种等位基因共有两个富含嘧啶基的内因子 ,并且每对标准基因均含有两种不同的富含嘧啶基内因子。此种强烈保守性与这些内含子的序列无关。基于基因组序列的对比研究所得到的上述发现提示基因组序列除了编码心脏肌球蛋白重链多肽的作用以外 ,还具有其他附加的功能。
The ratio of pyrimidinyl groups in the cardiac [alpha] and [beta] myosin heavy chain genes of humans and rats was studied. Exons encoding MyHC tail are all pyrimidinyl-deficient. This particular discovery, that some introns are pyrimidinyl-rich, and that the pyrimidinyl-rich state is preserved in both humans and rats, leaves all four alleles with two pyrimidinyl-rich intrinsic factors , And each pair of standard genes contains two different pyrimidinyl-rich intrinsic factors. This strong conservation is independent of the sequence of these introns. The above findings, based on a comparison of genomic sequences, suggest that the genomic sequence has other additional functions in addition to the role of the cardiac myosin heavy chain polypeptide.