【摘 要】
：
目的对经典抗癫痫药(AEDs)治疗效差的42例难治性癫痫(IE),包括部分性发作及/或全身强直阵挛性发作,少量Lennox-Gastaut综合征和West综合征等,加用托吡酯(TMP)观察其较长时期
【机 构】
：
首都医科大学北京友谊医院神经内科,;北京友谊医院神经内科进修医师,现在山西太原市人民医院
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目的对经典抗癫痫药(AEDs)治疗效差的42例难治性癫痫(IE),包括部分性发作及/或全身强直阵挛性发作,少量Lennox-Gastaut综合征和West综合征等,加用托吡酯(TMP)观察其较长时期的临床疗效和副反应.方法 TPM加治均期1年(6～19个月),用量50～500me/d(中位数为200mg),将每例最后3个月的平均月发作频率和中位数与基线进行比较,并观察副反应.结果总有效率(发作减少50%或以上)64.3%(P＜0.001),末次随诊有23.4%的病人发作控制3个月以上,副反应轻,多为一过性(71.2%),6.例病人因不能耐受副反应或疗效欠佳退出(退出率为14.3%).结论本研究提示TMP添加治疗IE疗效稳定,未见明显抗药性,是适于长期应用的新的有效AEDs之一.常见副反应与中枢神经系统有关.rn
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