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目的探讨胆囊结石与胆囊癌变的关系．方法１９７８年～１９９３年共收治原发性胆囊癌２２７例，男６０例，女１６７例，年龄３５岁～８３岁，平均５８１岁．进行了组织病理学及临床资料回顾分析．结果胆囊癌合并胆囊结石８３例，占３６６％，其中男性３３３％（２０／６０），女性３７７％（６３／１６７）均明显高于胆结石自然发病率，并随年龄增长而有增高趋势，５０岁以上者６５例（７８３％），各年龄组间有显著差异，病理学结果显示，胆结石所致的粘膜异型增生可癌变；本组腺癌最多，共６３例（８８７％）．结论胆囊结石可诱发癌变，应施行选择性预防胆囊切除术．
Objective To investigate the relationship between gallstones and gallbladder carcinogenesis. Methods From 1978 to 1993, a total of 227 cases of primary gallbladder cancer were treated, including 60 males and 167 females. The age ranged from 35 years to 83 years, with an average of 58 years and 1 year. A retrospective analysis of histopathology and clinical data was performed. Results There were 83 cases of gallbladder carcinoma with gallbladder stones, accounting for 36.6%, of which 33. 3% (20/60) were males, and 37.7% (63/167) were significantly higher than the natural incidence of gallstones. There was an increasing trend and there was an increasing trend. 65 patients (78. 3%) were over the age of 50. There was a significant difference among all age groups. The pathological results showed that dysplasia of the mucosa caused by gallstones could be cancerous; this group had the largest number of adenocarcinomas. 63 cases (88.7%). Conclusion Gallbladder stones can induce cancer, and selective cholecystectomy should be performed.