目的　评价立体定位穿刺留置导丝引导手术活检术对临床触诊阴性而乳腺X线摄影发现的隐匿性乳腺病变定位活检的价值。材料与方法　临床扪诊阴性 ,而乳腺X线片显示成簇的细小钙化、模糊小结节及局部结构紊乱等可疑的恶性病灶 ,通过计算机立体定位下穿刺 ,留置导丝于可疑的病灶区 ,然后手术取活体组织行病理学检查。结果　 31例患者 ,乳腺X线检查发现病灶34个 ,定位穿刺留置导丝 32根 ,导丝引导下手术活检 32例次均一次性成功定位与切除 ,定性诊断正确率为 10 0 %。病理检查结果 :恶性病变 9例次 11个病灶 ,良性病变 2 3例次。恶性病变中浸润性导管癌 4例次 5个病灶 ,导管内癌 3例次 ,乳腺单纯癌 2例次 3个病灶。结论　立体定位穿刺留置导丝引导手术活检术对乳腺隐匿性病变定位活检准确 ,既解决了外科医生术中对乳腺微小的病变定位的困难 ,又解决了盲目手术切除或针穿活检假阴性的问题。此技术创伤小 ,简单易行 ,是目前诊断早期乳腺癌的有效方法和技术保证 Objective To evaluate the value of stereotactic puncture indwelling guide wire guided surgical biopsy in the absence of clinical palpation negative mammography findings of occult breast lesion location biopsy. The materials and methods were clinically permissive and the mammographic X-ray showed clusters of suspicious malignant lesions such as small calcified, fuzzy nodules, and local structural disturbances. The needles were placed in a suspicious lesion area by computerized stereotactic puncture. Then take the biopsy to perform pathological examination. Results In 31 patients, 34 cases were found by X-ray examination of the mammary glands, 32 guidewires were indwelled by local puncture, and 32 cases underwent guide wire biopsy were successfully positioned and excised once. The diagnostic accuracy rate was 100%. Pathological findings: malignant lesions in 9 cases of 11 lesions, 23 cases of benign lesions. Among the malignant lesions, 5 were invasive ductal carcinomas, 3 were intraductal carcinomas, and 3 were breast cancers and 2 lesions. Conclusion The stereotactic puncture-guided indwelling guidewire-guided surgical biopsy is accurate in locating biopsy of occult breast lesions. It not only solves the surgeon’s difficulty in localizing the tiny lesions of the breast, but also solves the problem of blind or surgical needle punctures. . This technique is minimally invasive and easy to use. It is an effective method and technology guarantee for the diagnosis of early breast cancer.