1例72岁男性患者因不典型膜性肾病口服他克莫司(2 mg,2次/d)及甲泼尼龙(8 mg,1次/d)。约6个月后,患者出现纳差、口干、乏力。实验室检查示空腹血糖23.2 mmol/L,糖化血红蛋白13.1%。考虑药物相关性继发性糖尿病可能性大。停用他克莫司,换用吗替麦考酚酯500 mg,1次/12 h口服,甲泼尼龙原剂量继续应用,同时口服替米沙坦、胰岛素。4d后患者血糖相对稳定。 One 72-year-old male patient received oral tacrolimus (2 mg twice daily) and methylprednisolone (8 mg daily) for atypical membranous nephropathy. About 6 months later, patients with anorexia, dry mouth, fatigue. Laboratory tests showed fasting blood glucose 23.2 mmol / L, glycated hemoglobin 13.1%. Consider drug-related secondary diabetes is highly likely. Stop taking tacrolimus, for use with mycophenolate mofetil 500 mg, 1/12 h orally, the original dose of methylprednisolone continue to be used, while oral telmisartan, insulin. 4d after the patient’s blood glucose is relatively stable.