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自1958年 Ford 等首先在急性白血病(以下简称 AL)病人的骨髓中发现染色体异常后,AL 染色体的改变逐渐引起了人们的重视。最初,人们发现 AL 的染色体核型变化波动范围较广,以致,认为这些变化只是一种偶然现象,与白血病的发生学无关。1970年以来,由于显带技术的进展,使得人们能够准确地识别单个染色体以及每个染色体上的相应部分,因而在 AL 染色体的研究中,发现其核型变化并非杂乱无章,而是有某些规律性。近年来,通过细致的观察,认识到 AL 染色体的改变对临
Since 1958 Ford et al first found the chromosomal abnormalities in the bone marrow of patients with acute leukemia (hereinafter referred to as AL), AL chromosome gradually attracted people’s attention. Initially, it was found that the variation of karyotypes of AL chromosomes was so wide that they were considered as an accidental phenomenon, not related to the genesis of leukemia. Since 1970, due to advances in banding technology, allowing people to accurately identify a single chromosome and the corresponding part of each chromosome, so in the AL chromosome study found that the karyotypic change is not chaotic, but there are some rules Sex. In recent years, through careful observation, recognize the AL chromosome changes on the Pro