Arsenic trioxide (As2O3) is an effective agent used in tr-eatment of acute promyelocytic leukemia (APL). However, appearances of side effects using clinical therapeutic dosages of As2O3 occur during the initial or consolidated stage in APL therapy. We rep Arsenic trioxide (As2O3) is an effective agent used in tr-eatment of acute promyelocytic leukemia (APL). However, appearances of side effects using clinical therapeutic dosages of As2O3 occur during the initial or consolidated stage in APL therapy. We rep