观察中国眼镜蛇毒蛋白酶natrahagin对大鼠血液流变学和血浆纤维蛋白原水平的影响,发现natrahagin低剂量(0.025mg/kg)、中剂量(0.05mg/kg)以及高剂量(0.1mg/kg)静脉注射后,显著降低200、30、51/S各切变率下大鼠的全血粘度和血浆粘度(P<0.05或P<0.01),对红细胞压积无显著影响(P>0.05),同时可剂量依赖性地降低大鼠血浆纤维蛋白原浓度(P<0.05或P<0.01)。 Observing the effects of Natrahagin, a Chinese cobra venom protease, on hemorheology and plasma fibrinogen levels in rats, and found that natrahagin was administered at low doses (0.025 mg/kg), medium doses (0.05 mg/kg), and high doses (0.1 mg/kg). After intravenous injection, the whole blood viscosity and plasma viscosity of rats at the shear rates of 200, 30, and 51/S were significantly reduced (P<0.05 or P<0.01), and had no significant effect on the hematocrit (P>0.05). At the same time, the plasma fibrinogen concentration was reduced in a dose-dependent manner (P<0.05 or P<0.01).