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破伤风是士的宁样长效毒素所致的中枢神经系统中毒症,其症状取决于破伤风毒素的药效学和药动学,致死的基本原因是呼衰及继发性心血管功能障碍。尽管在治疗上进展显著,但死亡率仍高达40～60％。有人试用鞘内或脑池内注射破伤风抗毒素或鞘内注射皮质激素,效果均不肯定。有人应用鞘内注入氯苯氨丁酸(巴氯芬;baclo-fen)治疗脊髓性或脑性痉挛,已获成功,作者认为,可能是由于抑制脊髓内神经递质的作用。作者报道2例破伤风病人,试用鞘内注射氯苯氨丁酸治疗,并根据肌电图的肌肉动作电位的时间—电压积分判定疗效。
Tetanus is a strychnine-like central nervous system poisoning caused by long-acting toxins, the symptoms depend on the pharmacodynamics and pharmacokinetics of tetanus toxin, the basic cause of death is respiratory failure and secondary cardiovascular dysfunction . Despite the significant advances in treatment, the mortality rate is still as high as 40-60%. Some people try intrathecal or intracisternal injection of tetanus antitoxin or intrathecal corticosteroids, the effect is not sure. Someone has been successful in the treatment of spinal or cerebral spasm by intrathecal injection of baclofen (baclo-fen), which the authors believe may be due to the inhibition of neurotransmitters in the spinal cord. The authors report 2 patients with tetanus, try intrathecal chlorbenzidine treatment, and according to the EMG EMF time-voltage integral to determine the efficacy.