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目的:探讨曲美他嗪对慢性心力衰竭患者心功能及MMP-9、TIMP-1表达的影响。方法:选取2012年3月至2014年3月在我院接受治疗的慢性心力衰竭患者100例,随机分为观察组和对照组,每组50例。对照组给予常规药物治疗,研究组在对照组基础上加用曲美他嗪治疗。观察并比较两组患者心率(HR)、左心室射血分数(LVEF)及MMP-9、TIMP-1水平的变化情况。结果:与治疗前比较,两组患者治疗后心率降低,LVEF升高,差异具有统计学意义(P<0.05);观察组患者LVEF高于对照组,差异具有统计学意义(P<0.05);与治疗前比较,两组患者治疗后TIMP-1升高,MMP-9降低,差异具有统计学意义(P<0.05);与对照组比较,观察组患者治疗后TIMP-1升高,MMP-9降低,差异具有统计学意义(P<0.05)。观察组治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05)。结论:盐酸曲美他嗪用于治疗慢性心力衰竭具有良好的疗效,不仅可以调节血清MMP-9及TIMP-1水平,而且能够改善患者心功能。
Objective: To investigate the effect of trimetazidine on cardiac function and the expression of MMP-9 and TIMP-1 in patients with chronic heart failure. Methods: One hundred patients with chronic heart failure treated in our hospital from March 2012 to March 2014 were randomly divided into observation group and control group with 50 cases in each group. The control group was given conventional drug treatment, and the study group was treated with trimetazidine on the basis of the control group. The changes of heart rate (HR), left ventricular ejection fraction (LVEF), MMP-9 and TIMP-1 levels in the two groups were observed and compared. Results: Compared with those before treatment, the heart rate and LVEF increased after treatment in both groups (P <0.05). The LVEF in observation group was higher than that in control group (P <0.05). Compared with those before treatment, TIMP-1 increased and MMP-9 decreased after treatment in both groups (P <0.05). Compared with the control group, the patients in the observation group showed increased TIMP-1 and MMP- 9 decreased, the difference was statistically significant (P <0.05). The total effective rate of observation group was significantly higher than the control group, the difference was statistically significant (P <0.05). Conclusion: Trimetazidine hydrochloride has good curative effect in the treatment of chronic heart failure. It not only can regulate the levels of serum MMP-9 and TIMP-1, but also improve the cardiac function of patients.