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目的对60例2型糖尿病口服降糖药仍难以控制血糖的患者给予睡前中效胰岛素加口服降糖药的疗效观察。方法60例2型糖尿病随机分为2组,A组瑞格列奈2mg,三餐时服,中效胰岛素每日睡前(22:00)皮下注射。B组二甲双胍0.53次/d口服,中效胰岛素每日睡前(22:00)皮下注射,中效胰岛素初始量,根据患者体质量按0.2u/(kg.d)计算。结果治疗12周后2组患者的空腹(FPG)餐后2h血糖(2hPG),糖化血红蛋白(HbA1C)均较治疗前显著性降低(均P<0.01)。结论睡前中效胰岛素(NPH)加口服降糖药物治疗是治疗2型糖尿病的确切方法。
Objective To observe the curative effect of preemergence insulin plus oral hypoglycemic agents on 60 patients with type 2 diabetes who are still difficult to control blood sugar by oral hypoglycemic agents. Methods 60 cases of type 2 diabetes mellitus were randomly divided into two groups, A group repaglinide 2mg, three meals a day, medium-acting insulin daily before bedtime (22:00) subcutaneous injection. Group B metformin 0.53 times / d oral, medium-dose insulin daily before going to bed (22:00) subcutaneous injection, the initial dose of insulin in effect, according to the patient’s body mass calculated by 0.2u / (kg.d). Results After 12 weeks of treatment, fasting (FPG) 2hPG and HbA1C in both groups were significantly lower than those before treatment (both P <0.01). Conclusion Preoperative bedtime insulin (NPH) plus oral hypoglycemic agents is the treatment of type 2 diabetes mellitus.