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目的:探讨妊娠期梅毒患者妊娠结局的影响因素。方法:回顾性分析70例妊娠期梅毒患者按首次筛查时的孕周(是否>孕28周)、分娩时的血清TRUST滴度(是否<1∶8)及有无进行规范治疗进行分组,分析梅毒孕产妇的妊娠结局情况。结果:①筛查孕周<28周组先天梅毒的发生率为5.36%(3/56);孕周≥28周组先天梅毒的发生率为35.71%(5/14),两组比较,差异有统计学意义(P<0.05)。②分娩时孕母的血清TRUST滴度<1∶8组先天梅毒的发生率为2.04%(1/49);滴度≥1∶8组先天梅毒的发生率为53.85%(7/13),两组比较,差异有统计学意义(P<0.05)。③规范治疗组发生不良妊娠结局者占5.00%(2/40),未治疗组占73.33%(22/30),两组比较,差异有统计学意义(P<0.05);两组先天梅毒的发生率分别为2.50%(1/40)和23.33%(7/30),两组比较,差异有统计学意义(P<0.05)。结论:梅毒孕产妇未早期筛查、分娩时血清学TRUST滴度高(滴度≥1∶8)及未规范治疗是发生先天梅毒等不良妊娠结局的重要因素。
Objective: To investigate the influencing factors of pregnancy outcome in syphilis during pregnancy. Methods: A retrospective analysis of 70 patients with gestational syphilis gestational age at the first screening (whether> 28 weeks pregnant), serum TRUST titers (<1: 8) at childbirth, and the presence or absence of normative treatment were grouped, Analysis of syphilis maternal pregnancy outcome. Results: ①The incidence of congenital syphilis in the screening gestational week <28 weeks group was 5.36% (3/56); the incidence of congenital syphilis was 35.71% (5/14) in the gestational weeks ≥28 weeks group. The differences between the two groups There was statistical significance (P <0.05). (2) TRUST titers of serum of pregnant mothers during labor were less than 1: 8 (2.04%) (1/49); titers of syphilis ≥ 1: 8 were 53.85% (7/13) The difference between the two groups was statistically significant (P <0.05). ③ The standard treatment group had adverse pregnancy outcomes accounted for 5.00% (2/40), untreated group accounted for 73.33% (22/30), the difference between the two groups was statistically significant (P <0.05); two groups of congenital syphilis The incidence rates were 2.50% (1/40) and 23.33% (7/30) respectively. There was significant difference between the two groups (P <0.05). CONCLUSIONS: Syphilis pregnant women have not been screened early. Serum TRUST titers (titers ≥1: 8) during childbirth and non-standardized treatment are important factors for adverse pregnancy outcomes such as congenital syphilis.