研究 5种具有良好的抗氧化和抗菌活性的新型化合物———富马酸甲 (乙、丙、丁、戊 )·3 PG酯的合成工艺条件并揭示了其规律。发现富马酸单酯单酰氯与没食子酸丙酯 (PG)的理想反应条件为 :在c(PG) =5 7 0 1mol/L的吡啶溶液中 ,吡啶正常回流温度下 ,分别缓慢滴加富马酸单甲 (乙、丙、丁、戊 )酯单酰氯 ,反应 4 0～ 6 0min ,可获得产率为 75 6 % (78 3%、83 8%、83 3%、76 5 % )的富马酸甲 (乙、丙、丁、戊 )·3 PG酯。随烷基碳链的增长 ,马来酸酐与醇的物质的量比减小 ,反应温度升高和反应时间延长 Five novel compounds with good antioxidant and antibacterial activities were synthesized and their regularities were studied. The ideal reaction conditions of fumaric acid monoester monochloride and propyl gallate (PG) were found as follows: in a pyridine solution of c (PG) = 5 7 0 1mol / L, pyridine was added dropwise at normal reflux temperature The yield is 756% (78 3%, 83 8%, 83 3%, 76 5%) of the Fumarate A (B, C, D, E) 3 PG ester. With the increase of alkyl carbon chain, the molar ratio of maleic anhydride to alcohol is decreased, the reaction temperature is increased and the reaction time is prolonged