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[目的]比较醋酸甲羟孕酮联合NP方案与单用NP方案治疗中晚期非小细胞肺癌的近期疗效、毒副反应及生活质量。[方法]71例中晚期非小细胞肺癌患者随机分为醋酸甲羟孕酮+NP方案治疗组(32例)与NP方案组(39例)。两组均以21天为1个周期,治疗2个周期。[结果]两组近期疗效无显著性差异。NP方案加醋酸甲羟孕酮组生存质量明显改善、进食量和体重显著增加及恶心呕吐毒副反应明显低于单纯NP方案组。[结论]醋酸甲羟孕酮联合NP方案治疗中晚期肺癌患者有效率无明显提高,但毒副反应低、耐受性好。
[Objective] To compare the short-term curative effect, side effects and quality of life of medroxyprogesterone acetate plus NP and NP alone in the treatment of advanced non-small cell lung cancer. [Method] 71 patients with advanced non-small cell lung cancer were randomly divided into Medroxyprogesterone acetate plus NP regimen (n = 32) and NP regimen (n = 39). Two groups were 21 days for a cycle, treatment 2 cycles. [Results] There was no significant difference between the two groups in the short term efficacy. NP program plus medroxyprogesterone acetate group significantly improved the quality of life, food intake and body weight increased significantly and nausea and vomiting toxicity was significantly lower than the simple NP program group. [Conclusion] The efficacy of medroxyprogesterone acetate combined with NP regimen in the treatment of advanced lung cancer patients has no obvious improvement, but the toxicity is low and the tolerance is good.