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血红素加氧酶(HO)是血红素降解的起始酶和限速酶,其主要功能是代谢血红素成为一氧化碳、胆绿素及铁离子。HO-1是HO的一种同工酶,为诱导型HO。HO-1及血红素代谢产物具有抗炎、抗氧化、抗凋亡、扩张血管等生理作用。HO-1作为一种重要的应激蛋白,在急性肾脏损伤、肾小球肾炎、肾间质纤维化等肾脏疾病的病理生理发展过程中发挥着重要的保护作用,有效地调控其表达有可能成为预防和治疗相关疾病的新策略。
Heme oxygenase (HO) is the initial enzyme and the rate-limiting enzyme for heme degradation. Its main function is to metabolize heme to carbon monoxide, biliverdin, and iron ions. HO-1 is an isozyme of HO, an inducible HO. HO-1 and heme metabolites have anti-inflammatory, anti-oxidant, anti-apoptotic, dilated blood vessels and other physiological effects. As an important stress protein, HO-1 plays an important protective role in the pathophysiology of renal diseases such as acute kidney injury, glomerulonephritis and renal interstitial fibrosis, and it is possible to effectively regulate its expression Become a new strategy for the prevention and treatment of diseases.