论文部分内容阅读
目的:分析甲胎蛋白(AFP)及甲胎蛋白异质体L3(AFP-L3)在肝癌患者切除术前后的变化情况,探讨AFP-L3对肝癌患者术后的预后判断价值。方法:采集98例确诊为肝癌的患者于手术切除前、后的连贯血清(术前1份,术后连续留取),应用甲胎蛋白异质体微量离心柱分离并洗脱获得AFP-L3,再同时检测原始血清中AFP及AFP-L3含量,计算AFP-L3在总AFP中比率(AFP-L3%≥10%为阳性),对比手术切除前、后AFP含量及AFP-L3%的变化情况。结果:术后2个月AFP-L3阳性患者在未来28个月内的生存几率明显降低,AFP-L3阴性患者生存几率高;术后6个月AFP-L3阳性患者在未来24个月内的生存几率明显降低,AFP-L3阴性患者生存几率是100%;术后第l2个月AFP-L3阳性患者在未来18个月内的生存几率明显降低,AFP—L3阴性患者生存几率是100%。结论:AFP-L3对肝癌患者术后预后的判断具有重要的临床指导意义。
Objective: To analyze the changes of alpha-fetoprotein (AFP) and alpha-fetoprotein heterologous L3 (AFP-L3) in patients with hepatocellular carcinoma before and after resection, and to explore the value of AFP-L3 in the prognosis of patients with hepatocellular carcinoma. Methods: 98 consecutive patients with hepatocellular carcinoma who were diagnosed with hepatocellular carcinoma were consecutively excised before and after surgical resection (1 preoperatively, consecutively after surgery). AFP-L3 was isolated and eluted with alpha-fetoprotein hetero-microcentrifuge column and eluted. , At the same time, the levels of AFP and AFP-L3 in the original serum were measured, and the ratio of AFP-L3 in total AFP (AFP-L3% ≥10% was positive) was calculated. The changes of AFP content and AFP-L3% before and after surgical resection were compared. Happening. Results: The probability of survival of AFP-L3 positive patients within 2 months after surgery was significantly lower in the next 28 months, and the survival rate of AFP-L3 negative patients was high; within 6 months of AFP-L3 positive patients within the next 24 months The probability of survival was significantly reduced, and the survival rate of AFP-L3 negative patients was 100%. The survival chance of AFP-L3 positive patients in the next 18 months was significantly lower in the next 18 months, and the survival rate of AFP-L3 negative patients was 100%. Conclusion: AFP-L3 has important clinical guiding significance for the prognosis of patients with hepatocellular carcinoma.