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目的探讨胎盘炎性病理变化与高危妊娠的关系。方法对94例初产足月孕妇进行Edward高危评分,≥7分者61例诊断为高危妊娠为观察组,<7分者33例为低危对照组,两组均行剖宫产终止妊娠,术中对胎盘取材病理检查,观察新生儿窒息情况。结果胎盘发生白细胞浸润、绒毛水肿、间质纤维组织增生、绒毛内纤维素沉积等炎症改变者,高危组明显高于低危组(P<0.05);新生儿窒息(Apgar评分≤7分)发生率,高危组明显高于低危组(P<0.05),经抢救后新生儿窒息好转(P>0.05)。结论胎盘炎性改变是导致高危妊娠的重要原因,易引起新生儿窒息。对高危妊娠应严密监测胎盘形态和功能,确保母婴安全。
Objective To investigate the relationship between placental inflammatory pathology and high-risk pregnancy. Methods 94 cases of primogenial full-term pregnant women with Edward high-risk score, ≥ 7 points in 61 cases diagnosed as high-risk pregnancy as observation group, <7 points 33 cases of low-risk control group, both groups were cesarean termination of pregnancy, Intraoperative placenta taken from the pathological examination, observation of neonatal asphyxia. Results Placental infiltration of leucocytes, villus edema, interstitial fibrosis, villus fibrin deposition and other inflammatory changes were significantly higher in the high-risk group than in the low-risk group (P <0.05); neonatal asphyxia (Apgar score ≤ 7 points) occurred Rates and high-risk groups were significantly higher than those in low-risk groups (P <0.05). After resuscitation, neonatal asphyxia improved (P> 0.05). Conclusion Placental inflammatory changes are important causes of high-risk pregnancies and can easily lead to neonatal asphyxia. High-risk pregnancy should be closely monitored placental morphology and function, to ensure the safety of mother and child.