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The synthesis of selenamorpholine hydrate was described and its antimutagenic effects were investigated by the Ames tests. The results indicated that the mutation induced by the indirect mutagen 2-AF was inhibited obviously by selenamorpholine hydrate at the dosage of Se 0. 16--100 ug /dish for 35. 8% -53. 7% (TA_97) and the mutation induced by direct mutagen Dexon was inhibited for 6. 2% --30. 0% (TA_97,) and 2. 3% ~34. 1% (TA_100). The mutagenesis of the indirect mutagen cyclophosphamide was suppressed for 5.4%~ 16. 1% by selenamorpholine hydrate at the dosage of Se 0. 16--100 ug /dish.
The synthesis of selenamorpholine hydrate was described and its antimutagenic effects were investigated by the Ames tests. The results indicated that the mutation induced by the indirect mutagen 2-AF was impeached obviously by selenamorpholine hydrate at the dosage of Se 0. 16--100 ug / dish for 35. 8% -53. 7% (TA_97) and the mutation induced by direct mutagen Dexon was inhibited for 6. 2% - 30. 0% (TA_97,) and 2.3% ~ 34.1% (TA_100). The mutagenesis of the indirect mutagen cyclophosphamide was suppressed for 5.4% ~ 16.1% by selenamorpholine hydrate at the dosage of Se 0. 16--100 ug / dish.