论文部分内容阅读
目的 研究心律安口服液抗大、小鼠心肌缺血及抗心律失常作用。方法 用氯仿致小鼠心律失常、用氯化钡致大鼠心律失常、乌头碱致大鼠心律失常 ,大鼠冠状动脉结扎致心律失常 ,以观察不同剂量的心律安口服液对大、小鼠心律失常的保护作用。结果 心律安各剂量组能明显拮抗氯仿对小鼠所致的室颤发生率 ,也能降低冠脉结扎再灌注大鼠的心律失常 ;心律安各剂量组能延长氯化钡、乌头碱所致大鼠室速、室颤和死亡时间 ,同时也加快心律的恢复。结论 心律安口服液能拮抗心肌缺血和心律失常 ,其机理可能通过影响心肌细胞膜钾、钠离子传递系统 ,降低心肌自律性 ,延长绝对不应期 ,从而抑制异位节律点的作用
Objective To study the effects of Xinluan Oral Liquid on myocardial ischemia and antiarrhythmic effects in rats and mice. Methods Arrhythmia induced by chloroform in mice, arrhythmia induced by lanthanum chloride in rats, arrhythmia induced by aconitine in rats, and arrhythmia induced by coronary artery ligation in rats were observed. Rat arrhythmia protection. RESULTS: The different doses of heart rate antler could significantly antagonize the incidence of ventricular fibrillation induced by chloroform in mice, and could also reduce the arrhythmia induced by coronary artery ligation and reperfusion in rats. Each dose of heart rate antler group could prolong the growth of cesium chloride and aconitine. Caused by rat ventricular tachycardia, ventricular fibrillation and death time, but also to speed up the recovery of heart rate. Conclusion Xinfuan oral liquid can antagonize myocardial ischemia and arrhythmia. The mechanism may be through affecting the potassium and sodium ion transmission system of myocardial cell membrane, reducing myocardial autonomy, and extending the absolute refractory period, thus inhibiting the effect of ectopic rhythm.