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肠出血性大肠杆菌(Enterohemorrhagic Escherichia coli,EHEC)通过其Ⅲ型分泌系统将效应因子注入到宿主细胞内,破坏宿主细胞内的多种信号通路从而有利于细菌的感染及定植。近年来对于EHEC Ⅲ型分泌系统效应因子与宿主细胞相互作用研究成为EHEC致病机制研究新的热点,研究表明,除了经典的效应因子外,一些新发现的效应因子在细菌的致病过程中也发挥着重要作用,有些效应因子能够抑制宿主细胞内正常的信号通路,有些效应因子还具有抑制细胞凋亡,干扰炎症信号通路和抑制吞噬的作用。这些发现揭示了EHEC效应因子具有多种功能,它们通过与宿主细胞间的相互作用,在细菌的感染过程中发挥着重要作用。
Enterohemorrhagic Escherichia coli (EHEC), through its type III secretion system, injects effector into host cells, destroying various signaling pathways in host cells and facilitating bacterial infection and colonization. In recent years, studies on the interaction between EHEC type Ⅲ secretion factor and host cells have become new hot topics in the pathogenesis of EHEC. Studies have shown that in addition to classical effect factors, some newly discovered effect factors are also found in pathogenesis of bacteria Play an important role. Some effectors can inhibit the normal signal pathways in host cells. Some effectors also have the effects of inhibiting apoptosis, interfering with inflammatory signaling pathway and inhibiting phagocytosis. These findings reveal that EHEC effectors have multiple functions and that they play an important role in bacterial infection through their interaction with host cells.