目的总结体外循环手术中抢救鱼精蛋白毒性反应的治疗经验。方法 18例鱼精蛋白毒性反应患者,应用体外循环辅助循环、应用肾上腺素药物及钙剂;并加快输血速度、补足血容量等方法,抢救患者。结果 17例经加快输血速度,应用钙剂、肾上腺素、激素、抗组胺药物等处理抢救成功。1例术后出现顽固性低心排综合征,12 h后突然发生室颤,抢救无效死亡。结论应用鱼精蛋白时严密观察病情变化,根据病情变化及时应用体外循环、肾上腺素等方法可取得良好效果。 Objective To summarize the therapeutic experience of rescue protamine toxicity during cardiopulmonary bypass. Methods 18 cases of protamine toxic reaction patients, application of cardiopulmonary bypass assisted circulation, the application of adrenergic drugs and calcium; and speed up the blood transfusion speed, make up blood volume and other methods to rescue patients. Results 17 cases of accelerated blood transfusion, the application of calcium, epinephrine, hormones, antihistamines and other treatment rescue success. 1 case of intractable low cardiac output syndrome, 12 h after the sudden onset of ventricular fibrillation, died of rescue ineffective. Conclusion The application of protamine when the close observation of changes in condition, timely application of cardiopulmonary bypass, adrenaline and other methods can be achieved good results.