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目的 早产儿视网膜病 (ROP)是儿童视觉损害及致盲的重要原因之一。众多的研究表明低出生体重和低胎龄是ROP发病的主要危险因素。该文旨在探讨除出生体重和胎龄外 ,影响ROP发生的其他危险因素。方法 根据胎龄、出生体重进行配对 ,合并ROP的早产儿和未合并ROP的早产儿各 32例进行对照研究 ,对2 0种可能的危险因素进行Logistic回归性分析。结果 氧疗时间 (DOT)、最高动脉氧分压 (MaxPaO2 )、妊娠高血压(PIH)、生后 3d内最低 pH值 (MinpH)的比值比 (OR)值分别为 2 .76 4、2 .1 75、1 .935、2 .4 1 7(P <0 .0 1 )。建立的早产儿ROP危险因素主效应模型是Logit(P) =β0 +1 .2 6 5DOT +1 .0 34MaxPaO2 +0 .936PIH - 1 .2 73MinpH (χ2 =2 5 .6 34,P <0 .0 1 )。结论 氧疗时间长、高氧血症、妊娠高血压和酸中毒为ROP的高危因素
Objective The retinopathy of prematurity (ROP) is one of the most important causes of visual impairment and blindness in children. Numerous studies have shown that low birth weight and low gestational age are the major risk factors for the development of ROP. This article aims to explore in addition to birth weight and gestational age, the impact of other risk factors for ROP. Methods According to gestational age, birth weight paired, premature infants with ROP and non-ROP preterm infants with 32 cases of each control study, 20 Logistic regression analysis of possible risk factors. Results The odds ratios (OR) of DOT, MaxPaO2, PIH and MinpH in 3 days after birth were 2.76 4,2. 1 75,1 .935,2. 4 1 7 (P <0 .01). The established principal effect model of risk factors for ROP in preterm infants was Logit (P) = β0 +1 .2 6 5DOT +1 .0 34MaxPaO2 +0.936PIH - 1 .2 73MinpH (χ2 = 2.56. 34, P <0. 0 1). Conclusions Oxygen therapy is a long-term risk factor for ROP in patients with hyperoxia, pregnancy-induced hypertension and acidosis